247-51 Shimpo

Aloe arborescens Miller var. natalensis Berger (Japanese name Kidachi aloe) is widely used in Japan, not only as a traditional remedy for gastrointestinal complaints, skin injury and burns, but also as an ingredient in health foods (Fujita, 1993; Yamamoto et al., 1995; Beppu et al., 2003). Previously, we demonstrated that freeze-dried whole leaves of Aloe arborescens var. natalensis (hereinafter called ALOE) inhibited the development of azoxymethane (AOM)induced aberrant crypt foci (ACF), a putative neoplastic lesion, in the rat colorectum, with increased quinone reductase activity in the liver (Shimpo et al., 2001a). We also showed that feeding Japanese Pharmacopoeia aloe and commercial crude aloin (Sigma A-0451; hereinafter ALOIN) suppressed the AOM-induced ACF formation in the rat Inhibition of Azoxymethane-induced DNA Adduct Formation by Aloe arborescens var. natalensis